Amazon CloudFront & Wordfence

We are in the process of updating our servers and I started looking at CDN's. So far, I like what I am seeing via Amazon Cloudfront. I was curious the easiest way to integrate AmazonCloudfront into a multisite config and if anyone knows of any issues with Wordfence?

I posted this to Wordfence as well, but I thought I would check with WPMU. Why... well you guys live it. :slight_smile:

Thanks again for all input.