Anti-Splog Rename wp-signup

I'm using the BP-Social theme and the Anti-Splog plugin.

In the Anti-Splog settings, the 'Rename wp-signup.php' option notes: "Not Buddypress compatible". I'd like some more details on this. I'd prefer that all registrations come from the WPMU side and not from BuddyPress or BBPress. However, my registration does have a required field for BuddyPress added to it.

So, can I use this option?