Anyone tried Smush Pro along with Imsanity Plugin?

The Imsanity Plugin is great for resizing on upload the massive images that users upload from their 20 megapixel cameras.

Smush Pro also operates on images as they are uploaded, sending them to an image server to be compressed.

Do they play well together? Which one does it's job first? Seems like it would make sense for Imsanity to go first, making a much smaller image to send to Smush Pro's servers.

Has anyone tried this?