Best Multisite Install For Addon Domains and Subdomains?

This will be my first multisite wp install and I want to get it right the first time if possible.

I have 19 domains, 1 primary and the rest are addon domains. I use subdomains on several of the addons and a few on the primary domain.

The host is hostmonster, with a dedicated ip. I have SSL on the primary with subdomains for secure links for credit card processing and others for secure access to facebook, etc.

I also want to host sites for the wp locu embedding http://en.support.wordpress.com/shortcodes/locu/ so, performance needs to be good. Would like to consider what is best for SEO too.

What would be the best multisite configuration for what I am trying to do?

Thanks

Chris