Best Multisite Install For Addon Domains and Subdomains?

This will be my first multisite wp install and I want to get it right the first time if possible.

I have 19 domains, 1 primary and the rest are addon domains. I use subdomains on several of the addons and a few on the primary domain.

The host is hostmonster, with a dedicated ip. I have SSL on the primary with subdomains for secure links for credit card processing and others for secure access to facebook, etc.

I also want to host sites for the wp locu embedding so, performance needs to be good. Would like to consider what is best for SEO too.

What would be the best multisite configuration for what I am trying to do?