Best way to combat spam for multisite?

Hello, I'm new to multi-site wordpress, am setting up a site, and I'd like some opinions on the best way to combat Spam.

Is the WPMU-Dev anti-spam pack a good alternative to Askimet? Or do they serve different purposes?

My main goal is make it seamless for multisite admins. I'd like all configuration to be done by super admin (me), so my users don't even have to worry about API keys or configurations.

Thanks in advance!