I'm having a strange permalink problem with only 2 profiles.
They only don't load on /%postname%/ When I change it to something else, they load fine.
Funny enough, all other profiles and everything else loads fine.
I'm running wp 3.0.4 and bp 1.2.7
I use marketpress which depends on the permalink structure as well and also the pretty links plugin.
Although disabling them makes no difference.
Here are the profiles: