Can I create a network on a domain mapped subblog?

Hi, I was wondering if the following scenario would be possible with either the Multi Domains plugin, the Domain Mapping plugin, both together or neither!

I have my network up and running, domain.com, offering subdomains.domain.com
I currently use Donncha's domain mapping plugin to allow mapping of cooluserdomain to cooluser.domain.com, but might switch to the WMPU dev version if needed (if it ain't broken...).

I want to set up another subdomain in this install, lets call it new.domain.com, and have new.com map to new.domain.com. That part is easy, but can I use the plugins then to:
(1) create subdomains off that mapped subdomain, i.e. newsub.new.com etc
(2) domain map those names as well : user.com goes to newsub.new.com?

Thanks in advance,
Cheers