Can make textual changes, can't make layout changes

I found several topics about not able to make changes, not any solution was given. My situation is like this:

When I change a text and click on 'Save', it's saved in the edit area and on the actual live frontpage.
When I delete a section and click on 'Save', it's saved in the edit area but not on the live frontpage. When I go back to the Upfront edit area the section is back.

In both situations I get this message when clicking on exit: 'You have unsaved changes you're about to lose by navigating off this page.' So even with the successful textual changes.

What I'm doing wrong?