I've got the Comment Spam Pack installed on our live site, and in one case, it's stopping me from leaving a comment on my own site.
I'm using a theme called SupportPress from WooThemes, which turns WP into a full on Support site (no need to pay for ZenDesk anymore).
Anyway, the theme creates a custom post type called "tickets" and you can "manage tickets" by adding a comment to an existing ticket.
Everything is working beautifully, except when I go to leave a comment on a ticket -- I get the dreaded "Cheating huh" message from the "AVH First Defense Against Spam - WPMU DEV Version" plugin.
I've turned off all the anti-spam options, but I'm still getting blocked from leaving a comment. Help!