Cloudfront and Smush Pro

I am looking for a way to compress my images that are being served via CloudFront. I was referred to use CloudFront by a very helpful support person here at WPMU. All of my speed tests recommend compression of a lot of recently uploaded images. when I task Smush Pro to compress the images, it returns an error message saying that the files can not be found. Is there a way to configure smush to be able to find the images in CloudFront or S3?