The Comment Spam Pack was proven very effective in fighting spam. But we all know it can be improved (like any other spam fighting tool).
I spite of making it a better pack, we added a new plugin: AVH First Defense Against Spam.
AVH First Defense Against Spam blocks spammers before any content is served by identifying them at the Project Honey Pot, a local blacklist or a local IP cache. It also checks, at stopforumspam.com, visitors trying to post a comment.
The version of this plugin included in the Comment Spam Pack is different from the original, as the settings are set sitewide on a Multisite install and individual bloggers don't have to mess up with them.
Hopefully this addition to the Comment Spam Pack will save you spam headache.
Download it, try it and let us know how it works for you.