confusion over site settings in multisite

I've been stumped over this for months and am wondering if its the source of strange behaviors between sites. Hoping that someone with more multisite experience can clear this up for me, as I've been unable to find answers elsewhere.

Here's the issue. In Network > Site Settings, I have five different sites using domain mapping. They each have a totally different list of settings. Some have home url fields, some don't. Some have blog description fields, others don't.

So one major question I hope to have solved -- why are the order and types of fields displayed totally different and does this have any larger impact on usability or functionality?