Controlling Groups / URLs

Howdy,

Can you please clarify what sorts of control I'll have?

I have a large multi-site setup with the following structure:

domain1.com, domain2.com, domain3.com

subd1.dom1.com, sub2.dom2.com, sub3.dom3.com, etc.

I would like to know if I can create a group, call it "exclude all dom3.com subdomains" and then make any member a part of that group. And similar configurations.

Thanks!