Can I simply delete blog slug?

Hey!

Is there any reason why one couldn't just delete the slug "blog" in the db wp_options > permalink_structure (multisite install)? Is there a reason why that is a bad idea? Because I've seen this plugin http://buddydev.com/plugins/remove-blog-slug-plugin/
granted, it's not a lot of code, but, ...again, just looking to understand if there's a reason not to delete.

Big thanks!
-jennyb