directory plugin - drill down multi level + search

Hi, thanks for taking a moment.
My goal is to great a health oriented web magazine with a practioner directory in it.
Is it possible to install the directory plugin on a studiopress/genesis theme, so one tab in the nav bar would be "directory" and then create a national directory, that could drill down several levels... For example...
"directory/State/city/practitioner" or "directory/practitioner/state/city". As well, I'd like to be able to search by zipcode.
Any insight would be greatly appreciated.
Thanks so much & best,