Directoy Header Error

I am in the middle of creating a new site using the directory plugin and all of the sudden I receive this error when trying to login or navigate the site:

Warning: Cannot modify header information – headers already sent by (output started at /home1/******/public_html/******/wp-settings.php:340) in /home1/******/public_html/******/wp-includes/pluggable.php on line 934

It is making the wp-admin page inaccessible as well.

Can someone please help me debug this issue?

Thanks in advance!

Jeff