Does BuddyPress affect or limit network sub site options?

Does BuddyPress affect how network sites work? Will any site/theme/blog/plugin that runs on a Wordpress network run as a BuddyPress member site. I am not asking about the main top network site which obviously needs a BuddyPress theme. I am wondering if I can convert a current WP network to BP without any negative imp at on all the sites running on the network.