Does Defender potentially cause indexing issues with Google?

Hi Gurus,
I've never used Defender before, so I thought I'd try it out.
I'm getting weird responses from various online tools that I normally have no problem with.
When I submit my website to https://www.google.com/webmasters/tools/mobile-friendly/?url=ecoevolver.com it says it can't fetch the URL
When I submit to https://gtmetrix.com/ it also says it can't access the site.
The google PageSpeed insights plugin can't run reports on my site.

Has anyone every reported issues like this when using Defender? Thanks!