Domain Mapping, AJAX, Constantly Slow

So I contacted you all about this 6 months ago and so far no one has actually updated with any fixes, so I am opening a new ticket to see if any one has a fresh idea or opinion on it.

Issue-
WordPress Multisite with Domain Mapping, have over 250 mapped domains.
It is constantly slow until we deactivate the domain mapping plugin and then activate it again. Lasts maybe 3 hours then gets slow again.
When I login to NewRelic the issue is definitely the Domain Mapping Plugin with /wp-admin/admin-ajax.php resources taking up 99.4% of time.

Server- 32GB RAM, Dedicated, Nginx with Apache

Is there anyway to prevent this as I have been having to reset this plugin every few hours, every day, and every night and I wish there was a way to not have this issue?