Domain Mapping on Amazon EC2

Hi, All.

I've successfully used domain mapping on various hosts, and even wrote a cpanel script to automatically park the mapped domains to the root cpanel upon user creation in wp-admin.

But what I'm curious to know is if anyone has experience or has successfully implemented Domain Mapping on Amazon AS3 or EC2 (not sure the terms).

Searched for posts to no avail, so apologies is this has been beaten to death already.
A link to the post would be sufficient.

My IT indicates it's trickier with their setup. Not sure if they even provide cpanel (-esque).

thanks in advance...