Domain mapping possible for a 3 server setup behind a load balancer?

Hi there, I would like to throw this into the mix.

We have 1 AWS Elastic Load Balancer that spreads traffic to 3 EC2 instances. Each instance is connected to a main DB server, but each has its own Elastic IP assigned.

Would domain mapping still work with this 3-IP setup? Would it be possible to use a CNAME of the load balancer for the mapping plugin pointing to domain.com rather than the A pointing to the 123.45.67.89 entry?

Additionally, I'm using the Route 53 DNS service to map mydomain.com to the load balancer directly.

Hope it makes sense, thanks!

Flo