Gloabl regions don't work and turning my work into hell!

Hi, the global regions are turning my website work into hell, i tried to modify some global regions and when saving, and it cost me a lot of time and hard work with no result, and when i create a new page, if i add a new global region like a secondary header or secondary footer ....... it appear then i continue working but once i save everything disseappear, it is really urning my work to hell, it lost me a lot of time, please fix this