Global Blog Theme and Plugin Options

We're fairly new to WPMU and wanting to set it up as a CMS so that each blog has the same options and navigation. IOW, the same basic framework but different information within pages and posts. For example, a breadcrumb plugin we use has to have all it's options set up within each blog so that it works the same within each blog, which gets pretty old when you have to go to the admin and then the backend over and over to standardize something across ten different subdomains.

Is there a way to tie themes and plugins together across all blogs so that they have the same appearance and options?