Global regions not saving

I have a existing global region in the footer, but when I edit any of the elements in that region, the changes do not take.

When I edit using Safari, the changes in my footer won't show up at all. I can see them initially in the editor, save, go to the live version of that page (Home), refresh, and nothing. Then if I exit that page in the editor and return, the changes are no longer in the editor.

When I edit using Firefox, I add a change to a footer element (global region) and I will see it on the Home page, but not on any other existing pages on the site.

Both behaviors are not consistent with the expectation of a global region's behavior.