Has anyone had any file contention or locking issues while running Snapshot?

As I'm building my site and its size increases, I'm using Snapshot to back up the site on a regular question. As my site gets bigger and snapshots take longer I was wondering what might happen when Snapshot encounters a locked file/table or even a locked record.

Has anyone encountered file contention or locking issues or have potential problems such as those been handled well in Snapshot?