HELP - HELP - HELP - we are speachless... and helpless

Valued Support Team

last we did was updating BuddyPress... result, we have on many irregular pages and sub domains by sudden 404 and content is not protected like it should.

We tried to help ourself by
- cleared browser cache
- clear super cache
- re-set Permalinks on all multi sites

but we do not get rid of that 404 error and content protection, apart from other issue, like missing navigation etc.

Attached screenshot to demonstrate a bit what we experience.

Please help urgently.
BIG THANKS
Prinz