How (or) is it possible to nest WP multisites?

Hi,

Im looking to develop multiple sites, each requiring distinct multisites of their own with subdirectories – is this possible and, if it is, how so? I know mastersite.com + site1 & site2 = site1.mastersite.com & site2.mastersite.com, but can these subdomains have distinct subdirectory sites of their own as well?

Before I try and tackle this, I thought Id reach out.

Thanks,

Mads