How to Reset Multisite Network without 'www' in Front of the URL

I'm writing to see if it is safe to tweak the settings in the "Network Setup" option in the 'Settings' menu to not include 'www' without losing the settings, plugins, themes, integrations, etc. that I have already put in place.

I ask because I'm starting to see conflicts (for example: when trying to set up a Snapshot of a subdomain, it is unsuccessful because of the 'www' in the front of the network's primary domain.

For example, if I remove the 'www' from:

define('DOMAIN_CURRENT_SITE', '');

in the wp-config.php file, would it wreck the multisite network I set up?