I read the article 9 top CDN Services.. and I am curious if the lack of a CDN for multisite

I read the article 9 top CDN Services.. and I am curious if the lack of a CDN for multisite regards to a multisite that has multiple domains mappted to it, and or sub domains and or sub folders.

I would immagine that if a site has sub folders, it MIGHT be ok to work on a CDN.

Any wisdom here?