I want to know if I can use Custompress to redesign mu

I want to know if I can use Custompress to redesign mu home/post page. It’s currently a single post with a side bar. Ultimately, I want to get to a multi-panel news layout (news, ads, links via stepwise additions) and be able to position them where I want. Since I can’t program my way out of a wet paper bag, can Custompress do what’s needed? If not what to use?