Is is possible to use W3 Total Cache with the Multie Site?

Is is possible to use W3 Total Cache with the Multie Site?

I tried WP Super Cache -
And it somehow trashed my site. It would not work and then the un-install corrupted something. It just went to hell. So after paying someone to fix it I will not let that happen again.

Need a GOOD cache solution that will work with Amazon CDN.

Thank you!

(Just looking for a solution - Not wanting rehash what went wrong lat time)
Thanks -