Is it possible to integrate pro sites in a multi-network environment?

I am working on a local project where a multi-network environment may be useful. There are different multi-network plugins like network+ or wp-multi-networks available. My question is: does pro sites works with multi-networks?

For example with network+ they use subdomains for each network and subdirectories for the subblogs in each network (as I can understand from the litterature. So I can have a network called; now, can I use the pro sites plugin to create subblogs for client restaurants: sort like and so on, charging a fee for restaurant1, restaurant2 and so on?

Thanks for helping