Is there a downside to using multiple anti-spam plugins?

I have been constantly attacked by spam registrations on my site with fake names and hotmail/gmail .ru emails. I blocked all Chinese IPs but still get hit hard for some reason I don't understand.

So my question is I've found a couple plugins that use invisible fields, javascript and cookies to catch spam bots like this one:
http://geek.ryanhellyer.net/products/spam-destroyer/

and this one:
https://wordpress.org/plugins/spamlord/

Does it pose a potential risk or downside to use both plugins at once?

Optimally I have another solution I'd like to add but nobody's made such a plugin yet!

I want to be able to create a list of approved Facebook Groups and Twitter Bio Keywords and run a check as users login via a social login app to qualify and approve them to register/login.

Thank you WPMUdev!!!

Joe