Lightbox/Shadowbox/Colorbox Suggestions?

Good morning!

I was curious if anyone had any suggestions for a Lightbox/Shadowbox/Colorbox plugin that works with multisite? It needs to automatically add the code to images (our clients aren’t tech savvy enough to do it on their own) and have the capabilities to iFrame a page or video (manually is fine).

We were previously using Lightbox Plus and it worked great, however it no longer works with the most recent version of WordPress and it might also be conflicting with Thesis with the iFrame page/video (we’re still trying to confirm that).

We also use NEXTgen, so it would also be nice if we could locate a plugin that utilizes Shutter so we don’t have competing image plugins.