UPFront: Multilingual

Little question about the right approach to create a multilingual site;
1. Which build-up approach is best here? Should I mainly focus on creating regions? https://premium.wpmudev.org/blog/upfront-regions/
2. Which translation plugin is recommended? Looking for Vietnamese and Japanese translations.
Btw. I'd prefer manual translation! Vietnamese definitely will not work automated.
2b. For another site I'd need NL + EN, guess this one could be automated.
3. Any tips anyone would have are welcome.

ps. every time I create a question I need to edit the title, because it defaults to taking the first line of the message and use that as a title: maybe someone could have a look at that?