Mailchimp newsletter different lists

Is it possible to subscribe different users into different lists before feeding them to MailChimp. I read on MailChimp that:

Groups: MailChimp allows you to segment based on interest, engagement and more, so you can tailor your message to your audience.

Is it possible to use certain "user meta fields" to group users and send the different groups to MailChimp automatically?

Here is a question by paulchilds I copied from wordpress.org who had similar question 2 years ago:

"I want to be able to put different users into different categories - but not change anyone's access rights.

For example - say I have Bob, John, Sue & Alison on my blog - I would like to create a group that says Bob & ALison play the guitar and John & Sue play keyboard... etc - you get the idea.

I would then like to be able to send an email out to, e.g., only the guitarists, or only the keyboard players etc."