making sure defender recognizes new domain

Hi,
I'm going to be moving a site that is being developed under a temporary domain to a new domain and will be using this plugin to update the urls:
https://wordpress.org/plugins/velvet-blues-update-urls/

Is there anything I need to keep in mind/know regarding defender and the other wpmu dev installed plugins when changing urls? do I need to change anything in the wpmu dev system or will it auto detect in defender?