Members URL slugs

I would like the member url structure on my buddypress site so that it has nothing in front of the member name:

ex http://mydomain.com/username

rather than http://mydomain.com/anything/username

Is this possible? I am aware of using "define( 'BP_MEMBERS_SLUG', 'a' );" to change the slug but I would like the slug to go away completely. Is mod rewrite the answer?