Membership 2 Pro activated with Network Protection, affiliates activated single-site then

I have Membership 2 Pro network activated with Network Protection set to true.

I activated affiliates plugin without any problem but when I activated the membership addon the site crashed with a 500 error. Removed affiliates plugin and site is fine. (This after the lovely article that just came out bashing affiliate systems)

Is this a known issue? I don't have very many plugins activated. Most from here on WPMUdev. Or do I need to activate the plugin network wide as well due to this configuration?

Thank you for your help, I'm ginving Membership 2 a second try here

I (used) to be a membership plugin zealot...