membership payment gateway changes fail

I get this message when trying to save changes on the PayPal Express Payment Gateway page:


You don't have permission to access /~rideadve/wp-admin/admin.php on this server.

Additionally, a 404 Not Found error was encountered while trying to use an ErrorDocument to handle the request.

I have tried CHMODDING via FileZilla on teh admin.php to 777 but still no luck.

Anyone have any ideas on this error?