Prior to Upfront 4.1, I used global regions to quickly create pages from a group of 'building blocks'. Now, when I add a new global region the plus sign that allows me to add a new region doesn't appear. The plus sign won't appear in that new region until I click another region, use that to add another region, and then go back.
This is a minor inconvenience, but I wanted to bring it to your attention so that you could add it to the fix list.
I've authorized support access in case you need to see my site.