MS buddypress and mapped directories, classified, and blog sites

I’m venturing into new grown and have many questions
Will I be able to use wordpress MS and buddypress as a main site and have several directory, classified, and pay to blog premium blogs mapped to the main site? I would like to be able to allow members to have their own buddypress social network on the main site. I hope to eventually have up to 250 mapped domains.
Can I have both directory sites and classified sites mapped to the main site? Will there be a problem running these off of the same data base?