Multi- Domains- main domain wild card dns no longer available

I installed the multi-domain plugin and it was showing that my main domain was available under the wild card dns availability, I was able to create a test site this afternoon. Now it's showing unavailable. The only thing that I've done in the mean time that could have change it is install the Domain Mapping plugin, which mentioned to remove some coding from the wpconfig file during set up. Can this effect the multi-domain plugin?