Multi Domains-Separate Install also?

Quick question, if I use Multi Domains on a network I run am I still able to have a separate WordPress install using one of the added domains?

Would this affect it in any way? For example my network is say and I add a domain to the first network using multi domains and creating the wildcard subdomain.

Can I at the same time have set up as a separate wordpress install and successfully run sites there as well? or would it conflict?