Multisite Enabled- main site not accessable!

My site becomes inaccessible after enabling the multisite Network, I have completed the process of editing the wp-config.php and .htaccess files, following the instructions
of copying and pasting details from network setup. I am bare metal box running zen-server and a turnkey Linux appliance in a virtual machine. The site is just fine as a stand alone install of WordPress...only becomes inaccessible after the file are uploaded by ftp to the site..wp-admin login is fails, and the mail site's theme goes crazy in color and no images..I have worked on this now for a week, and have successfully configured multisites before, I need a new set of eyes to help!
I am building this site for local school district for educational school and teacher sites.