Multisite via Subdomain and Subdirectory

Hi there WPMUDEV

I don’t know how complex this might be as I’ve never done it before, hence I created a ticket instead asking in an online chat so that you may discuss it before committing to anything should it be needed as I know it to be possible but not very common as Multisite isn’t everybody’s favorite but I have stumbled upon it before, can’t recall exactly where so I can’t refer to any documentation, but here’s the request:

Can a domain run WordPress in both Subdomain and Subdirectory on the WPMUDEV hosting platform?