Notice: Constant MULTISITE already defined in wp-config.php on line

Notice: Constant MULTISITE already defined in wp-config.php on line

I am doing a custom installation of WP MS with a renamed installation directory and a moved content directory. Everything is defined where I am seeing the site and function as expected. This is pre enable WP Multisite in the wp-config.php

I am right now getting this debug error notice and it is not showing the Network Settings Enabling options under tools which I presume is due to the notice.

My question, is this possibly due to a .htaccess configuration
(which is modified to accommodate my custom directories configurations for version control purposes)
Or is this due to a different cause/source?

Recommendations as to where to narrow my troubleshooting are VERY MUCH appreciated.

Regards!