Point email hosting and web hosting to separate cPanel account under same IP address/server?

Is it possible to have a sub-site that have domain mapping, but at the same time the domain name have another cPanel account under same server (and IP address)?

I have a existing domain that pointed to a cPanel account for email hosting for quite time and having a lots of email data inside. However i wish to point the same domain to multisite for web hosting, which under same server but different cPanel account. Is it possible?