Potential conflict between using a CDN and WP Smush.it?

I am moving towards using W3 Total Cache with the Amazon Cloudfront CDN (chosen because they have a CDN server here in Sydney ... and most of my site visitors will be based in Australia). I also have installed the WP Smush.it plugin for image compression.

Because the CDN helps with speedier load times for image files, will I in fact be causing myself problems with also using WP Smush.it?

Thanks ... Michael